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蕭孟芳 教授 (Shaio, Men-Fang)


1983~ 1985 英國倫敦大學 臨床熱帶醫學系 哲學博士

1982~ 1983 英國倫敦大學 臨床熱帶醫學系 碩士

1972 ~1979 國防醫學院 醫學系 學士


2010~       國立陽明大學熱帶醫學科教授  

2001 ~ 2010 弘光科技大學 營養醫學教授  

2001 ~ 2005 弘光科技大學 基礎醫學教授

2000 ~ 2001 弘光科技大學 教授兼副校長

1998 ~ 2001 國防醫學院 預防醫學研究所 所長

1990 ~ 2001 國防醫學院 寄生蟲暨熱帶醫學科 教授兼科主任



1989 ~ 2001 國防醫學院 寄生蟲暨熱帶醫學科 教授

1985 ~ 1989 國防醫學院 寄生蟲暨熱帶醫學科 副教授

1979 ~ 1982 國防醫學院 寄生蟲暨熱帶醫學科 助教








1. 美國微生物學學會

2. 英國皇家衛生及熱帶醫學學會


3. 美國免疫學學會

4. 國際傳染病學會




國科會研究傑出獎(1990, 1991)


Scientific Citation Index Publications (1991-2010)


Selected Publications


1. Shaio, M.F., F.Y. Chang, S.C. Hou, C.S. Lee, and P.R. Lin. 1991.  Role of immunoglobulin and complement in enhancing the respiratory burst of neutrophils against Trichomonas vaginalis. Parasite Immunol. 13:241-250.

2. Ding, Y.A., C.L. Han, T.C. Chou, W.Y. Lai, and M.F. Shaio. 1991. Effect of isradipine on platelet aggregation and oxygen free radicals in hypertension. J Hypertens. 9(Suppl):S370-S371. 

3. Wang, J.J., C. Hu, F. Lee, M.F. Shaio, and L.K. Chen. 1991. Internalization of CD4 molecules in normal human CD4+ T cells by immunoelectron microscopic labeling.  Histochemistry. 97:51-59.


4. Shaio, M.F., P.R. Lin, C.S. Lee, S.C. Hou, P. Tang, and K.D. Yang. 1992. A novel neutrophil-activating factor released by Trichomonas vaginalis. Infect Immun. 60: 4475-4482.

5. Shaio, M.F., F.Y. Chang, and S.C. Hou. 1992. Complement pathway activity in serum from patients with classical dengue fever.  Trans Roy Trop Med Hyg. 86:672-675. 

6. Hsieh, K.H., and M.F. Shaio. 1992. Thymopentin therapy in severe atopic dermatitis: clinical and immunological evaluations. Arch Dis Child. 67: 1095-1102. 

7. Chen, A., W.Y. Chou, S.L. Ding, and M.F. Shaio. 1992. Glomerular localization of nephritogenic protein complexes on a non-immunological basis. Lab Invest. 67:175-185.

8. Yang, K.D., W.Y. Liou, C.S. Lee, M.L. Chu, and M.F. Shaio. 1992. Effects of phenobarbital on the leukocyte activation: membrane potential, actin polymerization, chemotaxis, respiratory burst, cytokine production, and lymphocyte proliferation. J Leukocyte Biol. 52: 151-156.

9. Yang, K.D., R. M. Stone, C.S. Lee, T.Y. Chao, S.N. Cheng, and M.F. Shaio. 1992. Effect of picibanil (OK432) on neutrophil-mediated antitumor activity: implication of monocyte-derived neutrophil-activating factors. Cancer Immunol Immunother.35: 277-282.

10. Ding, Y.A., C.L. Han, T.C. Chou, W.Y. Lai, and M.F. Shaio. 1992. Effects of the calcium antagonist isradipine on 24-hour ambulatory blood pressure, platelet aggregation, and neutrophil oxygen free radicals in hypertension. J Cardiovasc Pharmacol. 19(suppl):32-37.


11. Shaio, M.F., P.R. Lin, and C.S. Lee. 1993. Killing of Trichomonas vaginalis by complement-mediated lysis is not associated with the presence of Trichomonas vaginalis virus. Int J Parasitol . 23:675-680.

12. Yang, K.D., S.N. Cheng, N.C. Wu, and M.F. Shaio. 1993. Induction of interleukin-8 expression in neuroblastoma cells by retinoic acid: implication of leukocyte chemotaxis and activation. Pediatric Research 34: 720-724.

13. Tai, J.H., H.M. Su, J. Tsai, A. L. Wang, M.F. Shaio, and C.C. Wang. 1993. The divergence of Trichomonas vaginalis virus RNAs among various isolates of Trichomonas vaginalis. Exp Parasitol. 76: 278-286.


14. Shaio, M.F., K.P. Hwang, C.S. Lee, C.S.Suen, and K.D. Yang. 1994.  Influence of dengue virus infetion on the uptake and the respiratory burst activity of human monocytes.  Immunol Infect Dis 4:69-75.

15. Shaio, M.F., P.R. Lin, J.Y. Liu, and K.D. Yang. 1994. Monocyte-derived interleukin-8 involved in the recruitment of neutrophils induced by Trichomonas vaginalis infection.  J Infect Dis 170: 1638-1640.

16. Chang, D.M., and M.F. Shaio. 1994. Production of interleukin-1 (IL-1) and IL-1 inhibitor by human monocytes exposed to dengue virus. J  Infect Dis 170: 811-817.

17. Chen, A., S.L. Ding, L.F. Sheu, Y.B. Song, S.D. Shieh, M.F. Shaio, W.Y. Chou, and S.D. Shieh. 1994. Experimental IgA nephropathy: Enhancement of glomerular IgA immune complex deposition in proteinuric states.  Lab Invest 70: 637-647.

18. Yang, K.D., N.H. Augustine, M.F. Shaio, J.F. Bohnsack, and H.R. Hill. 1994. Effect of fibronectin on actin organization and respiratory burst activity in neutrophils, monocytes, and macrophages.  J Cell Physiol. 158: 347-353.

19. Yang, K.D., and M.F. Shaio. 1994. Hydroxyl radicals as an early signal involved in phorbol ester-induced monocytic differentiation of HL 60 cells. Biochem Biophys Res Commun 200: 1650-1657.

20. Yang, K.D., M.F. Shaio, C.L. Wang, N.C. Wu, and R.M. Stone. 1994. Neuroblastoma cell-mediated leukocyte chemotaxis : lineage-specific differentiation of interleukin-8 expression.  Exp Cell Research 211: 1-5.


21. Shaio, M.F., and P.R. Lin. 1995. Leukotriene B4 levels in the vaginal discharges from cases of trichomoniasis. Ann  Trop Med  Parasitol 89: 85-88

22. Shaio, M.F.,  and P.R. Lin. 1995 Influence of humoral immunity on leukotriene B4 production by neutrophils in response to Trichomonas vaginalis stimulation.  Parasite Immunol 17:127-133.

23. Yang, K.D., C.S. Lee, M.L. Chu, and M.F. Shaio. 1995. A model to study cytokine profiles in primary and heterologously secondary dengue-2 virus infections.  Acta Virol 39: 19-22. 

24. Shaio, M.F.,  S.N. Cheng, Y.S. Yuh, and K.D. Yang. 1995. Cytotoxic factors released by dengue virus-infected human blood monocytes. J Med Virol  46: 216-223.

25. Yang, K.D., C.L. Wang, and M.F. Shaio. 1995. Production of cytokines and platelet activating factor in secondary dengue virus infections. J Infect Dis 172: 604-605

26. Yang, K.D., H.L. Chuen, and M.F. Shaio. 1995. Pentoxifylline augments but not antagonizes TNF alpha-mediated neuroblastoma cell differentiation: modulation of calcium mobilization but not cAMP.  Biochem Biophys Res Commun 211: 1006-1014.

27. Shaio, M.F., P.R. Lin, J.Y. Liu, and K.D. Yang. 1995.  Generation of interleukin-8 from human monocytes in response to Trichomonas vaginalis stimulation. Infect Immun 63:3864-3870.

28. Chang, F.Y., and M.F. Shaio. 1995. Decreased cell-mediated immunity in patients with non-insulin-dependent diabetes mellitus.  Diabetes Res Clin Pr 28: 137-146.

29. Chang, F.Y., and. M.F. Shaio. 1995.  Respiratory burst activity of monocytes from patients with non-insulin-dependent diabetes mellitus.  Deabetes Res Clin Pr 29: 121-127.

30. Yang, K.D., C.S. Lee, and M.F. Shaio. 1995.   A higher production of platelet activating factor in ex vivo heterologously secondary dengue-2 virus infections.  Acta Microbiologica et Immunologica Hungarica 42: 403-407.


31. Lin, Y.F., D.M. Chang, M.F. Shaio, K.C. Lu, S.H. Chyr, B.L. Li, and S.D. Sheih. 1996. Cytokine production during hemodialysis: The effects of dialytic membrane and complement activation. Am J Nephrol 16: 293-299.

32. Chang, F.Y., and M.F. Shaio. 1996. Pentoxifylline pretreatment enhances the oxidative burst activity of human peripheral blood mononuclear cells.  Microbiol Immunol 40: 787-790.


33. Shaio, M.F., P.R. Lin, and J.Y. Liu. 1997. A colorimetric one-tube nested polymerase chain reaction for the detection of Trichomonas vaginalis in vaginal discharge.  J Clin Microbiol 35: 132-138.

34. Lin, P.R., M.F. Shaio, and J.Y. Liu. 1997. One-tube nested polymerase chain reaction assay for the determination of Trichomonas vaginalis  in vaginal discharges.  Ann  Trop Med  Parasitol 91: 61-65.


35. Shaio, M. F.,  and K.D. Yang.  1997. Response of Babesiosis to Azithromycin Therapy. Trans Roy Soc Trop Med Hyg 91: 214-215.

36. Yuh, Y.S., J.Y. Liu, and M.F. Shaio. 1997. Chromosome number of Trichomonas vaginalis.  J Parasitol 83: 551-553.

37. Shaio, M.F., and P.R. Lin. 1997. A case study on the cytokine profiles in acute human babesiosis. Am J Trop Med Hyg 58:335-337.


38. Shaio, M.F., and P.R. Lin. 1998. A case study on the cytokine profiles in acute human babesiosis. Am J Trop Med Hyg 58:335-337

39. Shaio, M.F., P.Wang , C.S. Lee, P.F.G. Sims, and J.E. Hyde. 1998.

Development and commparison of quantitative assays for the dihydropteroate synthetase codon 540 mutation associated with sulfadoxine resistance in Plasmodium falciparum.Parasitology 116:203-210

40. Yang, K.D., C.Y. Chao, and M.F. Shaio. 1998. Pentoxifylline synergizes with all-trans retinoic acid to induce differentiation of HL-60 myelocytic cells, but suppresses tRA-augmented clonal growth of normal CFU-GM. Acta Haematol 99:191-199.

41. Chen, A., L.F. Sheu, M.F. Shaio, T.H. Huang, S.L. Ding, and W.H. Lee. 1998. Antiidiotype antibody directly interferes with glomerular IgA immune complex deposition. Nephron 78:464-473.


42. Chang, W.K., Yang, K.D., and Shaio, M.F. 1999. Effect of glutamine on Th1 and Th2 cytokine responses in human peripheral blood mononuclear cells. Clin Immunol 93:294-301

43. Chang, W.K., Yang, K.D., and Shaio, M.F. 1999. Lymphocyte proliferation modulated by glutamine: involved in the endogenous redox reaction. Clin Exp Immunol 117: 482-488.


44. Shyu, R.H., M.F. Shaio, S.S. Tang, H.F. Shyu, C.F. Lee, M.H. Tsai, J.E. Smith, H.H. Huang, J.J. Wey, J.L. Huang, and H.H. Chang. 2000.  DNA Vaccination Using the Fragment C of Botulinum Neurotoxin Type A Provided Protective Immunity in Mice. J Biomed Sci 7:51-57

45. Jan, J.T., B.H. Chen, S.H. Ma, C.I. Liu, H.P. Tsai, H.C. Wu, S.Y. Jiang, K.D. Yang, and M.F. Shaio. 2000. A potential dengue virus-triggered apoptotic pathway in human neuroblastoma cells: arachidonic acid, superoxide anion, and NK-κB are sequentially involved. J. Virol 74: 8680-8691.

46. Shangkuan, Y.H., J.F. Yang, H.C. Lin, and M.F. Shaio. 2000. Comparison of PCR-RFLP, ribotyping and ERIC-PCR for typing Bacillus anthracis and Bacillus cereus strains.  J Appl Microbiol 89: 452-462.

47. Yang, K.D., M.Z. Chen, R.J. Teng, M.Y. Yang, H.C. Liu, R.F. Chen, T.Y. Hsu, and M.F. Shaio. 2000. A model to study antioxidant regulation of endotoxemia-modulated neonatal granulopoiesis and granulocyte apoptosis.  Pediatr Res 48: 829-834.

48. Weng, M.H., M.F. Shaio, and C.W. Yao. 2000. Failure of dengue-2 virus antibody to interfere with the isolation of dengue-2 virus from Aedes aegypti (Diptera:Culicidae). J Med Entomol 37: 641-644.  


49. Ho, L.J., J.J. Wang, M.F. Shaio, C.L. Kao, D.M. Chang, S.W. Han, and J.H. Lai. 2001. Infection of human dendritic cells by dngue virus causes cell maturation and cytokine production. J Immunol 166: 1499-1506.  


50. Wu, H.C., and M.F. Shaio. 2001. Identification of B cell epitope of dengue virus type 1 and its application in diagnosis of patients.  J Clin Microbiol 39: 977-982

51. Yang, K.D., W.T. Yeh, M.Y. Yang, R.F. Chen, and M.F. Shaio. 2001. Antibody-dependent enhancement of heterotypic  dengue infections involved in suppression of interferon-gamma production.  J Med Virol 63: 150-157

52. Yeh, D.T., P.R. Lin, E.R. Chen, and M.F. Shaio. 2001. Current status of parasitic infections in . Chin J Microbiol Immunol Infect 34(3):155-60. Review.

53. Lai, J.H., L.J. Ho, K.C. Lu, D.M. Chang, M.F. Shaio, and S.W. Han. 2001. Western and Chinese antriheumatic drug-induced T cell apoptotic DNA damage utilize different caspase cascades and is independent of Fas/Fas ligand interaction. J Immunol 166: 6914-6924.

54. Shangkuan, Y.H., Y.H. Chang, J.F. Yang, H.C.Lin, and  M.F. Shaio. 2001. Molecular characterization of Bacillus anthracis using multiplex PCR, ERIC-PCR and RAPD. Lett Appl Microbiol 32: 139-145.

55. Wu, H.C., Y.L. Huang, S.C. Lai, Y.Y. Huang, and M.F. Shaio. 2001. Detection of Clostridium botulinum neurotoxin type A using immuno-PCR.  Lett Appl Microbiol 32: 321-325.

56. Huang, J.L., J.H. Huang, R.H. Shyn, C.W. Teng, Y.L. Lin, M.D. Kuo, C.W.Yao, and M.F. Shaio. 2001. High level of expression of recombinant dengue viral NS-1 protein and its potential use as a diagnostic antigen. J Med Virol 65: 553-560.

57.Kao C.L., M.C. Wu, Y.H. Chiu, J.L. Lin, Y.C. Wu, Y.Y. Yueh, Chen L.K. Chen, M.F. Shaio, and C.C. King. 2001. Flow cytometry compared with indirect immunofluorescence for rapid detection of dengue virus type 1 after amplification in tissue culture. J Clin Microbiol 39: 3672-3677.


58. Chang, W.K., K.D. Yang, H. Chuang, J.T. Jan, and M.F. Shaio. 2002. Glutamine protects activated human T cells from apoptosis by up-regulating glutathione and bcl-2  levels. Clin Immunol 104: 151-158.



59. Wu, H.C.,  M.Y. Jung, C.Y. Chiu, T.T. Chao, S.C. Lai, J.T. Jan, and M.F. Shaio. 2003. Identification of a dengue virus type 2 (DEN-2) serotype-specific B-cell epitope and detection of DEN-2-immunized animal serum samples using epitope-based antigen. J Gen Virol 84: 2771-2779.

60. Wu, S.F., C.L. Liao, Y.L. Lin, C.T. Yeh, L.K. Chen, Y.F. Huang, H.Y. Chou, J.L. Huang, M.F. Shaio, and H.K. Sytwu. 2003. Evaluation of protective efficacy and immune mechanisms of using a non-structural protein NS1 in DNA vaccine against dengue 2 virus in mice. Vaccine 21: 3919-3929.

61. Huang, S.J., R.C.C. Wu, M.F. Shaio, P.S. Wang, and W.L. Cho. 2003. An immune signalling kinase AaMEK3 from mosquitoes: cDNA cloning and characterization. Insect Mol Biol 12: 595-603.


62. Yang, K.D., W.T. Yeh, R.F. Chen, H.L. Chuon, H.P. Tsai, C.W. Yao, and M.F. Shaio. 2004. A model to study neurotropism and persitency of Japanese encephalitis virus infection in human neuroblastoma cells and leukocytes. J Gen Virol 85: 635-642.

63.Chou, Y.K., H.J. Chen, M.F. Shaio, and Y.M. Kuo. 2004. In vitro antibiotic susceptibility of lactobacilli isolated from commercial products containing active lactobacilli. Acta Paediatr . 453: 141-144

64. Ho, L.J., M.F. Shaio , D.M. Chang, C.L. Liao, and J.H. Lai. 2004. Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines. Immunol Invest. 334: 423-437.

65. Yeh, W.T., R.F. Chen , L.Wang ,J.W.Liu , M.F. Shaio, and K.D.Yang. 2006.  

Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever. FEMS Immunol Med Microbiol. 48: 84-90.  



66. Chen TL, Siu LK, Wu RC, Shaio MF, Huang LY, Fung CP, Lee CM, Cho WL.Comparison of one-tube multiplex PCR, automated ribotyping and intergenic spacer (ITS) sequencing for rapid identification of Acinetobacter baumannii.

Clin Microbiol Infect 2007 Aug;13(8):801-6.

67.Chen-Chin WuR, Shaio M.F.,ChoW.L. A p38 MAP kinase regulates the expression of the Aedes aegypti defensin gene in mosquito cells. Insect Mol Biol. 2007 Aug;16(4):389-99

68. Tsui PY, Tsai KH, Weng MH, Hung YW, Liu YT, Hu KY, Lien JC, Lin PR, Shaio MF, Wang HC, Ji DD.Molecular detection and characterization of spotted fever group rickettsiae in Taiwan.Am J Trop Med Hyg 2007 Nov;77(5):883-90


69. Chen TL, Wu RC, Shaio MF, Fung CP, Cho WL. Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. Antimicrob Agents Chemother 2008 Jul;52(7):2573-80.


70. Lee PW, Liu CT, Rampao HS, do Rosario VE, Shaio MF. Pre-elimination of malaria on the island of Principe . Malaria Journal, 2010 Jan 20;9(1):26.

71. Lee PW, Liu CT, do Rosario VE, de Sousa B, Rampao HS, Shaio MF. Potential threat of malaria epidemics in a low transmission area, as exemplified by STP. Malaria Journal 2010, 9:264